The MHC Class II-Associated Chicken Invariant Chain Shares Functional Properties with Its Mammalian Homologs
Identifieur interne : 003688 ( Main/Exploration ); précédent : 003687; suivant : 003689The MHC Class II-Associated Chicken Invariant Chain Shares Functional Properties with Its Mammalian Homologs
Auteurs : Bj Rn Bremnes [Norvège] ; Marit Rode [Norvège] ; Merete Gedde-Dahl [Norvège] ; Tommy W. Nordeng [Norvège] ; Jorunn Jacobsen [Norvège] ; Scott A. Ness ; Oddmund Bakke [Norvège]Source :
- Experimental Cell Research [ 0014-4827 ] ; 2000.
English descriptors
- KwdEn :
- Teeft :
- Amino, Amino acid level, Amino acid sequence, Antigenic peptides, Bakke, Beta chains, Biol, Bremnes, Cdna, Cell surface, Cells transfected, Cells transiently transfected, Chemical crosslinking, Chii, Chii tail, Clip region, Clone, Cresswell, Cytoplasmic, Cytoplasmic tail, Embo, Endocytic, Endocytic pathway, Endoplasmic reticulum, Endosomal, Endosomal pathway, Endosomes, Glutamic acid, Histocompatibility, Human class, Immunol, Internalization, Intracellular, Intracellular transport, Invariant chain, Luminal, Luminal domain, Luminal part, Major histocompatibility, Mammalian, Mammalian orthologs, Murine, Mutant, Neuraminidase, Pathway, Peptide, Plasma membrane, Same experiment, Sequence similarity, Transfected, Transfection, Transmembrane, Transmembrane domain, Transmembrane region, Trimerization.
Abstract
Abstract: The nucleotide sequence of chicken invariant chain (Ii) was determined, and the amino acid sequence similarity with human Ii is 61%. Certain regions important for the biological function of human Ii are highly conserved between chicken and mammals. The cytoplasmic tail of chicken Ii fused to the plasma membrane reporter molecule neuraminidase relocated the protein to endosomes. Moreover, like the mammalian orthologs, the cytoplasmic tail was found to contain two independent leucine-based endosomal sorting signals. Chicken Ii was found to interact with human Ii and crosslinking studies also indicate that chicken Ii assembles as a trimer. The chicken Ii can furthermore bind the human MHC class II (HLA-DR1). Many of the functional properties between the chicken Ii and its mammalian orthologs are thus maintained in spite of their sequence differences.
Url:
DOI: 10.1006/excr.2000.4985
Affiliations:
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Box 1050 Blindern, 0316, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Ness, Scott A" sort="Ness, Scott A" uniqKey="Ness S" first="Scott A." last="Ness">Scott A. Ness</name><affiliation><wicri:noCountry code="subField">87131</wicri:noCountry></affiliation></author><author><name sortKey="Bakke, Oddmund" sort="Bakke, Oddmund" uniqKey="Bakke O" first="Oddmund" last="Bakke">Oddmund Bakke</name><affiliation wicri:level="3"><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Molecular Cell Biology, Department of Biology, University of Oslo, P.O. Box 1050 Blindern, 0316, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Experimental Cell Research</title><title level="j" type="abbrev">YEXCR</title><idno type="ISSN">0014-4827</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">259</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="360">360</biblScope><biblScope unit="page" to="369">369</biblScope></imprint><idno type="ISSN">0014-4827</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-4827</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MHC class II</term><term>chicken</term><term>endocytosis</term><term>invariant chain</term><term>leucine-based signal</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Amino</term><term>Amino acid level</term><term>Amino acid sequence</term><term>Antigenic peptides</term><term>Bakke</term><term>Beta chains</term><term>Biol</term><term>Bremnes</term><term>Cdna</term><term>Cell surface</term><term>Cells transfected</term><term>Cells transiently transfected</term><term>Chemical crosslinking</term><term>Chii</term><term>Chii tail</term><term>Clip region</term><term>Clone</term><term>Cresswell</term><term>Cytoplasmic</term><term>Cytoplasmic tail</term><term>Embo</term><term>Endocytic</term><term>Endocytic pathway</term><term>Endoplasmic reticulum</term><term>Endosomal</term><term>Endosomal pathway</term><term>Endosomes</term><term>Glutamic acid</term><term>Histocompatibility</term><term>Human class</term><term>Immunol</term><term>Internalization</term><term>Intracellular</term><term>Intracellular transport</term><term>Invariant chain</term><term>Luminal</term><term>Luminal domain</term><term>Luminal part</term><term>Major histocompatibility</term><term>Mammalian</term><term>Mammalian orthologs</term><term>Murine</term><term>Mutant</term><term>Neuraminidase</term><term>Pathway</term><term>Peptide</term><term>Plasma membrane</term><term>Same experiment</term><term>Sequence similarity</term><term>Transfected</term><term>Transfection</term><term>Transmembrane</term><term>Transmembrane domain</term><term>Transmembrane region</term><term>Trimerization</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The nucleotide sequence of chicken invariant chain (Ii) was determined, and the amino acid sequence similarity with human Ii is 61%. Certain regions important for the biological function of human Ii are highly conserved between chicken and mammals. The cytoplasmic tail of chicken Ii fused to the plasma membrane reporter molecule neuraminidase relocated the protein to endosomes. Moreover, like the mammalian orthologs, the cytoplasmic tail was found to contain two independent leucine-based endosomal sorting signals. Chicken Ii was found to interact with human Ii and crosslinking studies also indicate that chicken Ii assembles as a trimer. The chicken Ii can furthermore bind the human MHC class II (HLA-DR1). Many of the functional properties between the chicken Ii and its mammalian orthologs are thus maintained in spite of their sequence differences.</div></front></TEI><affiliations><list><country><li>Norvège</li></country><region><li>Østlandet</li></region><settlement><li>Oslo</li></settlement></list><tree><noCountry><name sortKey="Ness, Scott A" sort="Ness, Scott A" uniqKey="Ness S" first="Scott A." last="Ness">Scott A. Ness</name></noCountry><country name="Norvège"><region name="Østlandet"><name sortKey="Bremnes, Bj Rn" sort="Bremnes, Bj Rn" uniqKey="Bremnes B" first="Bj Rn" last="Bremnes">Bj Rn Bremnes</name></region><name sortKey="Bakke, Oddmund" sort="Bakke, Oddmund" uniqKey="Bakke O" first="Oddmund" last="Bakke">Oddmund Bakke</name><name sortKey="Gedde Dahl, Merete" sort="Gedde Dahl, Merete" uniqKey="Gedde Dahl M" first="Merete" last="Gedde-Dahl">Merete Gedde-Dahl</name><name sortKey="Jacobsen, Jorunn" sort="Jacobsen, Jorunn" uniqKey="Jacobsen J" first="Jorunn" last="Jacobsen">Jorunn Jacobsen</name><name sortKey="Nordeng, Tommy W" sort="Nordeng, Tommy W" uniqKey="Nordeng T" first="Tommy W." last="Nordeng">Tommy W. Nordeng</name><name sortKey="Rode, Marit" sort="Rode, Marit" uniqKey="Rode M" first="Marit" last="Rode">Marit Rode</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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